Glucose-fructose oxidoreductase domain-containing…

About Glucose-fructose oxidoreductase domain-containing protein 2

Glucose-fructose oxidoreductase domain-containing protein 2 (GFOD2) is a protein from Homo sapiens identified by UniProt accession Q3B7J2, 385 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Glucose-fructose oxidoreductase domain-containing protein 2
UniProt accession	Q3B7J2
Gene	GFOD2
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

lean body mass · score 0.12
red blood cell density measurement · score 0.09
balding measurement · score 0.06
mean corpuscular hemoglobin concentration · score 0.05
erythrocyte count · score 0.04
high density lipoprotein cholesterol measurement · score 0.04
hemoglobin measurement · score 0.03
hematocrit · score 0.03
refractive error · score 0.03
sleep duration · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3B7J2-F1	alphafold	PREDICTED	91.97	—

Amino-acid sequence (385 residues)

MKMLPGVGVF GTGSSARVLV PLLRAEGFTV EALWGKTEEE AKQLAEEMNI AFYTSRTDDI LLHQDVDLVC ISIPPPLTRQ ISVKALGIGK NVVCEKAATS VDAFRMVTAS RYYPQLMSLV GNVLRFLPAF VRMKQLISEH YVGAVMICDA RIYSGSLLSP SYGWICDELM GGGGLHTMGT YIVDLLTHLT GRRAEKVHGL LKTFVRQNAA IRGIRHVTSD DFCFFQMLMG GGVCSTVTLN FNMPGAFVHE VMVVGSAGRL VARGADLYGQ KNSATQEELL LRDSLAVGAG LPEQGPQDVP LLYLKGMVYM VQALRQSFQG QGDRRTWDRT PVSMAASFED GLYMQSVVDA IKRSSRSGEW EAVEVLTEEP DTNQNLCEAL QRNNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Glucose-fructose oxidoreductase domain-containing protein 2 (GFOD2)