Membrane-anchored junction protein (MAJIN)

About Membrane-anchored junction protein

Membrane-anchored junction protein (MAJIN) is a protein from Homo sapiens identified by UniProt accession Q3KP22, 176 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	Membrane-anchored junction protein
UniProt accession	Q3KP22
Gene	MAJIN
Organism	Homo sapiens
Length	176 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

urate measurement · score 0.37
serum metabolite measurement · score 0.16
azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.07
male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.07
spermatogenic failure 8 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3KP22-F1	alphafold	PREDICTED	60.87	—

Amino-acid sequence (176 residues)

MSLKPFTYPF PETRFLHAGP NVYKFKIRYG KSIRGEEIEN KEVITQELEV PVEKKAVGAV MRKRKHMDEP SSPSRPGLDR AKIGTSSQGP SKKKPPVETR RNRERKTQQG LQETLASDIT DVQKQDSEWG HSLPGRIVPP LQHNSPPPKE RAATGFFGFL SSLFPFRYFF RKSSHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards