About Protein Aster-B
Protein Aster-B (GRAMD1B) is a protein
from Homo sapiens identified by UniProt accession
Q3KR37, 738 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Protein Aster-B |
|---|
| UniProt accession | Q3KR37 |
|---|
| Gene | GRAMD1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 738 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (76)
Diseases linked to this target (Open Targets).
- chronic lymphocytic leukemia · score 0.45
- lymphocyte count · score 0.38
- testosterone measurement · score 0.37
- schizophrenia · score 0.34
- mean platelet volume · score 0.34
- serum IgM measurement · score 0.32
- heel bone mineral density · score 0.31
- lymphocyte percentage of leukocytes · score 0.31
- Hodgkins lymphoma · score 0.30
- multiple myeloma · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3KR37-F1 | alphafold | PREDICTED | 67.53 | — |
Amino-acid sequence (738 residues)
MKGFKLSCTA SNSNRSTPAC SPILRKRSRS PTPQNQDGDT MVEKGSDHSS DKSPSTPEQG VQRSCSSQSG RSGGKNSKKS QSWYNVLSPT YKQRNEDFRK LFKQLPDTER LIVDYSCALQ RDILLQGRLY LSENWICFYS NIFRWETLLT VRLKDICSMT KEKTARLIPN AIQVCTDSEK HFFTSFGARD RTYMMMFRLW QNALLEKPLC PKELWHFVHQ CYGNELGLTS DDEDYVPPDD DFNTMGYCEE IPVEENEVND SSSKSSIETK PDASPQLPKK SITNSTLTST GSSEAPVSFD GLPLEEEALE GDGSLEKELA IDNIMGEKIE MIAPVNSPSL DFNDNEDIPT ELSDSSDTHD EGEVQAFYED LSGRQYVNEV FNFSVDKLYD LLFTNSPFQR DFMEQRRFSD IIFHPWKKEE NGNQSRVILY TITLTNPLAP KTATVRETQT MYKASQESEC YVIDAEVLTH DVPYHDYFYT INRYTLTRVA RNKSRLRVST ELRYRKQPWG LVKTFIEKNF WSGLEDYFRH LESELAKTES TYLAEMHRQS PKEKASKTTT VRRRKRPHAH LRVPHLEEVM SPVTTPTDED VGHRIKHVAG STQTRHIPED TPNGFHLQSV SKLLLVISCV ICFSLVLLVI LNMMLFYKLW MLEYTTQTLT AWQGLRLQER LPQSQTEWAQ LLESQQKYHD TELQKWREII KSSVMLLDQM KDSLINLQNG IRSRDYTSES EEKRNRYH
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