About Probable RNA/DNA demethylase ALKBH6
Probable RNA/DNA demethylase ALKBH6 (ALKBH6) is a protein
from Homo sapiens identified by UniProt accession
Q3KRA9, 238 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Probable RNA/DNA demethylase ALKBH6 |
|---|
| UniProt accession | Q3KRA9 |
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| Gene | ALKBH6 |
|---|
| Organism | Homo sapiens |
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| Length | 238 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (16)
Diseases linked to this target (Open Targets).
- pancreatic neoplasm · score 0.07
- pentosuria · score 0.04
- histidinemia · score 0.03
- neoplasm · score 0.02
- cancer · score 0.01
- Alzheimer disease · score 0.01
- lung adenocarcinoma · score 0.01
- Pick disease · score 0.01
- low grade glioma · score 0.00
- lymph node metastatic carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3KRA9-F1 | alphafold | PREDICTED | 91.08 | — |
Amino-acid sequence (238 residues)
MEEQDARVPA LEPFRVEQAP PVIYYVPDFI SKEEEEYLLR QVFNAPKPKW TQLSGRKLQN WGGLPHPRGM VPERLPPWLQ RYVDKVSNLS LFGGLPANHV LVNQYLPGEG IMPHEDGPLY YPTVSTISLG SHTVLDFYEP RRPEDDDPTE QPRPPPRPTT SLLLEPRSLL VLRGPAYTRL LHGIAAARVD ALDAASSPPN AAACPSARPG ACLVRGTRVS LTIRRVPRVL RAGLLLGK
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