About Inactive Rho GTPase-activating protein 11B
Inactive Rho GTPase-activating protein 11B (ARHGAP11B) is a protein
from Homo sapiens identified by UniProt accession
Q3KRB8, 267 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Inactive Rho GTPase-activating protein 11B |
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| UniProt accession | Q3KRB8 |
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| Gene | ARHGAP11B |
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| Organism | Homo sapiens |
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| Length | 267 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- breast cancer · score 0.03
- neoplasm · score 0.02
- cancer · score 0.01
- Microcephaly · score 0.01
- Bartsocas-Papas syndrome 1 · score 0.01
- psoriasis · score 0.01
- schizophrenia · score 0.01
- breast ductal adenocarcinoma · score 0.01
- anxiety · score 0.00
- acute myeloid leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3KRB8-F1 | alphafold | PREDICTED | 78.09 | — |
Amino-acid sequence (267 residues)
MWDQRLVKLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP FNALPHSAVP EYGHIPSFLV DACTSLEEHI HTEGLFRKSG SVIRLKALKN KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE EKNKAILLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA PNLLQTSEGH EKMSSNAEKK GVYQTLSWKR YQPCWVLMVS VLLHHWKALK KVNMKLLVNI REREDNV
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