About TBC1 domain family member 25
TBC1 domain family member 25 (TBC1D25) is a protein
from Homo sapiens identified by UniProt accession
Q3MII6, 688 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | TBC1 domain family member 25 |
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| UniProt accession | Q3MII6 |
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| Gene | TBC1D25 |
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| Organism | Homo sapiens |
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| Length | 688 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (73)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.27
- retinitis pigmentosa · score 0.11
- X-linked retinal dysplasia · score 0.09
- age-related macular degeneration · score 0.09
- severe early-childhood-onset retinal dystrophy · score 0.08
- Familial exudative vitreoretinopathy · score 0.08
- Progressive cone dystrophy · score 0.07
- age related macular degeneration 4 · score 0.07
- age related macular degeneration 7 · score 0.07
- age related macular degeneration 11 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3MII6-F1 | alphafold | PREDICTED | 69.25 | — |
Amino-acid sequence (688 residues)
MATASGASDL SGSGAPPPGV GAQAAAAAEE EEREVVRVRV KKCESFLPPE FRSFAVDPQI TSLDVLQHIL IRAFDLSGKK NFGISYLGRD RLGQEVYLSL LSDWDLSTAF ATASKPYLQL RVDIRPSEDS PLLEDWDIIS PKDVIGSDVL LAEKRSSLTT AALPFTQSIL TQVGRTLSKV QQVLSWSYGE DVKPFKPPLS DAEFHTYLNH EGQLSRPEEL RLRIYHGGVE PSLRKVVWRY LLNVYPDGLT GRERMDYMKR KSREYEQLKS EWAQRANPED LEFIRSTVLK DVLRTDRAHP YYAGPEDGPH LRALHDLLTT YAVTHPQVSY CQGMSDLASP ILAVMDHEGH AFVCFCGIMK RLAANFHPDG RAMATKFAHL KLLLRHADPD FYQYLQEAGA DDLFFCYRWL LLELKREFAF DDALRMLEVT WSSLPPDPPE HEVELVGPPS QVADAGFGGH RGWPVRQRHM LRPAGGGGST FEDAVDHLAT ASQGPGGGGR LLRQASLDGL QQLRDNMGSR RDPLVQLPHP AALISSKSLS EPLLNSPDPL LSSFSHPDSP SSSSPPSTQE ASPTGDMAVG SPLMQEVGSP KDPGKSLPPV PPMGLPPPQE FGRGNPFMLF LCLAILLEHR DHIMRNGLDY NELAMHFDRL VRKHHLGRVL RRARALFADY LQSEVWDSEE GAEATAAS
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