tRNA pseudouridine synthase Pus10 (PUS10)

About tRNA pseudouridine synthase Pus10

tRNA pseudouridine synthase Pus10 (PUS10) is a protein from Homo sapiens identified by UniProt accession Q3MIT2, 529 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	tRNA pseudouridine synthase Pus10
UniProt accession	Q3MIT2
Gene	PUS10
Organism	Homo sapiens
Length	529 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 11A (Zellweger) · score 0.51
Zellweger syndrome · score 0.51
Crohn's disease · score 0.47
ulcerative colitis · score 0.47
inflammatory bowel disease · score 0.46
celiac disease · score 0.45
psoriasis · score 0.35
lymphocyte count · score 0.34
autoimmune disease · score 0.31
ankylosing spondylitis · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3MIT2-F1	alphafold	PREDICTED	88.32	—

Amino-acid sequence (529 residues)

MFPLTEENKH VAQLLLNTGT CPRCIFRFCG VDFHAPYKLP YKELLNELQK FLETEKDELI LEVMNPPPKK IRLQELEDSI DNLSQNGEGR ISVSHVGSTA SKNSNLNVCN VCLGILQEFC EKDFIKKVCQ KVEASGFEFT SLVFSVSFPP QLSVREHAAW LLVKQEMGKQ SLSLGRDDIV QLKEAYKWIT HPLFSEELGV PIDGKSLFEV SVVFAHPETV EDCHFLAAIC PDCFKPAKNK QSVFTRMAVM KALNKIKEED FLKQFPCPPN SPKAVCAVLE IECAHGAVFV AGRYNKYSRN LPQTPWIIDG ERKLESSVEE LISDHLLAVF KAESFNFSSS GREDVDVRTL GNGRPFAIEL VNPHRVHFTS QEIKELQQKI NNSSNKIQVR DLQLVTREAI GHMKEGEEEK TKTYSALIWT NKAIQKKDIE FLNDIKDLKI DQKTPLRVLH RRPLAVRARV IHFMETQYVD EHHFRLHLKT QAGTYIKEFV HGDFGRTKPN IGSLMNVTAD ILELDVESVD VDWPPALDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards