About Uncharacterized aarF domain-containing protein kinase 5
Uncharacterized aarF domain-containing protein kinase 5 (ADCK5) is a protein
from Homo sapiens identified by UniProt accession
Q3MIX3, 580 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Uncharacterized aarF domain-containing protein kinase 5 |
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| UniProt accession | Q3MIX3 |
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| Gene | ADCK5 |
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| Organism | Homo sapiens |
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| Length | 580 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (33)
Diseases linked to this target (Open Targets).
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.06
- nephrotic syndrome · score 0.06
- attention deficit hyperactivity disorder · score 0.06
- focal segmental glomerulosclerosis · score 0.05
- proteinuria, chronic benign · score 0.05
- Tourette syndrome · score 0.05
- schizophrenia 15 · score 0.05
- attention deficit-hyperactivity disorder 8 · score 0.05
- hyperprolinemia type 1 · score 0.04
- nail-patella-like renal disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3MIX3-F1 | alphafold | PREDICTED | 82.40 | — |
Amino-acid sequence (580 residues)
MWRPVQLCHF HSALLHSRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV LSTAVVGAPL LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD YWWCTNVVLR GVEENSPGYL EVMSACHQRA ADALVAGAIS NGGLYVKLGQ GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ EVDELFLEDF QALPHELFQE FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG DIHTLELLLR LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ IFYTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL WRAIILRDDA AMRAHAAALG VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE EAAYMVDMAR ERFEAVMAVL RELPRPMLLV LRNINTVRAI NVALGAPVDR YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK FEVALRLETL AMRLTALLAR ALVHLSLVPP AEELYQYLET
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