About Cytosolic phospholipase A2 epsilon
Cytosolic phospholipase A2 epsilon (PLA2G4E) is a protein
from Homo sapiens identified by UniProt accession
Q3MJ16, 868 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Cytosolic phospholipase A2 epsilon |
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| UniProt accession | Q3MJ16 |
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| Gene | PLA2G4E |
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| Organism | Homo sapiens |
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| Length | 868 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- 3-hydroxypropylmercapturic acid measurement · score 0.30
- neurofibrillary tangles measurement · score 0.20
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.14
- functional brain measurement · score 0.13
- brain volume measurement · score 0.12
- brain measurement · score 0.12
- blood protein measurement · score 0.06
- acne inversa, familial, 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3MJ16-F1 | alphafold | PREDICTED | 81.39 | — |
Amino-acid sequence (868 residues)
MSLQASEGCP GLGTNVFVPQ SPQTDEEGSR SGRSFSEFED TQDLDTPGLP PFCPMAPWGS EEGLSPCHLL TVRVIRMKNV RQADMLSQTD CFVSLWLPTA SQKKLRTRTI SNCPNPEWNE SFNFQIQSRV KNVLELSVCD EDTVTPDDHL LTVLYDLTKL CFRKKTHVKF PLNPQGMEEL EVEFLLEESP SPPETLVTNG VLVSRQVSCL EVHAQSRRRR KREKMKDLLV MVNESFENTQ RVRPCLEPCC PTSACFQTAA CFHYPKYFQS QVHVEVPKSH WSCGLCCRSR KKGPISQPLD CLSDGQVMTL PVGESYELHM KSTPCPETLD VRLGFSLCPA ELEFLQKRKV VVAKALKQVL QLEEDLQEDE VPLIAIMATG GGTRSMTSMY GHLLGLQKLN LLDCASYITG LSGATWTMAT LYRDPDWSSK NLEPAIFEAR RHVVKDKLPS LFPDQLRKFQ EELRQRSQEG YRVTFTDFWG LLIETCLGDE RNECKLSDQR AALSCGQNPL PIYLTINVKD DVSNQDFREW FEFSPYEVGL QKYGAFIPSE LFGSEFFMGR LVKRIPESRI CYMLGLWSSI FSLNLLDAWN LSHTSEEFFH RWTREKVQDI EDEPILPEIP KCDANILETT VVIPGSWLSN SFREILTHRS FVSEFHNFLS GLQLHTNYLQ NGQFSRWKDT VLDGFPNQLT ESANHLCLLD TAFFVNSSYP PLLRPERKAD LIIHLNYCAG SQTKPLKQTC EYCTVQNIPF PKYELPDENE NLKECYLMEN PQEPDAPIVT FFPLINDTFR KYKAPGVERS PEELEQGQVD IYGPKTPYAT KELTYTEATF DKLVKLSEYN ILNNKDTLLQ ALRLAVEKKK RLKGQCPS
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