DDB1- and CUL4-associated factor 4-like protein 1…

About DDB1- and CUL4-associated factor 4-like protein 1

DDB1- and CUL4-associated factor 4-like protein 1 (DCAF4L1) is a protein from Homo sapiens identified by UniProt accession Q3SXM0, 396 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	DDB1- and CUL4-associated factor 4-like protein 1
UniProt accession	Q3SXM0
Gene	DCAF4L1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

unipolar depression · score 0.14
bipolar disorder · score 0.12
autism spectrum disorder · score 0.11
anorexia nervosa · score 0.09
attention deficit hyperactivity disorder · score 0.09
obsessive-compulsive disorder · score 0.09
Tourette syndrome · score 0.09
schizophrenia · score 0.09
depressive symptom measurement · score 0.07
type 1 diabetes mellitus · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3SXM0-F1	alphafold	PREDICTED	84.97	—

Amino-acid sequence (396 residues)

MEAERLRLLE EEAKLKKVAR MGFNASSMLR KSQLGFLNVT SYSRLANELR VSCMERKKVQ IRSLDPSSLA SDRFNFILAS TNSDQLFVVN QVEVEGSKYG IISLRTLKIP SFHVYVLRNL YVPNRKVKSL CWASLNQLDS HVLLCFEGIT DAPSCAVLLP ASRFLSVHTR VNQPGMLCSF QIPEAWSCAW SLNTRAYHCF SAGLSQQVLL TSVATGHQQS FDTSSDVLAQ QFASTAPLLF NGCRSGEIFA IDLRCRNRGK GWRATRLFHD SAVTSVQILQ EEQCLMASDM TGKIKLWDLR ATKCVRQYEG HVNESAYLPL HVHEEEGIVV AVGQDCYTRI WSLHDAHLLR TIPSPYSASE DDIPSVAFAS RLGGIRGAAP GLLMAVRQDL YCFPFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

DDB1- and CUL4-associated factor 4-like protein 1 (DCAF4L1)