About Keratin, type II cytoskeletal 71
Keratin, type II cytoskeletal 71 (KRT71) is a protein
from Homo sapiens identified by UniProt accession
Q3SY84, 523 residues long.
MolForge cross-references it against 0 known binders and
163 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 71 |
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| UniProt accession | Q3SY84 |
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| Gene | KRT71 |
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| Organism | Homo sapiens |
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| Length | 523 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (163)
Diseases linked to this target (Open Targets).
- Woolly hair · score 0.49
- isolated familial wooly hair disorder · score 0.36
- neurodegenerative disease · score 0.33
- balding measurement · score 0.28
- hair shape measurement · score 0.28
- hypotrichosis · score 0.20
- ovarian cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- breast adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3SY84-F1 | alphafold | PREDICTED | 70.12 | — |
Amino-acid sequence (523 residues)
MSRQFTCKSG AAAKGGFSGC SAVLSGGSSS SFRAGSKGLS GGFGSRSLYS LGGVRSLNVA SGSGKSGGYG FGRGRASGFA GSMFGSVALG PVCPTVCPPG GIHQVTVNES LLAPLNVELD PEIQKVRAQE REQIKALNNK FASFIDKVRF LEQQNQVLET KWELLQQLDL NNCKNNLEPI LEGYISNLRK QLETLSGDRV RLDSELRNVR DVVEDYKKRY EEEINKRTAA ENEFVLLKKD VDAAYANKVE LQAKVESMDQ EIKFFRCLFE AEITQIQSHI SDMSVILSMD NNRNLDLDSI IDEVRTQYEE IALKSKAEAE ALYQTKFQEL QLAAGRHGDD LKNTKNEISE LTRLIQRIRS EIENVKKQAS NLETAIADAE QRGDNALKDA RAKLDELEGA LHQAKEELAR MLREYQELMS LKLALDMEIA TYRKLLESEE CRMSGEFPSP VSISIISSTS GGSVYGFRPS MVSGGYVANS SNCISGVCSV RGGEGRSRGS ANDYKDTLGK GSSLSAPSKK TSR
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