About Forkhead box protein D4-like 6
Forkhead box protein D4-like 6 (FOXD4L6) is a protein
from Homo sapiens identified by UniProt accession
Q3SYB3, 417 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | Forkhead box protein D4-like 6 |
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| UniProt accession | Q3SYB3 |
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| Gene | FOXD4L6 |
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| Organism | Homo sapiens |
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| Length | 417 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (8)
Diseases linked to this target (Open Targets).
- visual perception measurement · score 0.09
- Isolated anophthalmia - microphthalmia · score 0.05
- Microphthalmia - ankyloblepharon - intellectual disability · score 0.05
- nanophthalmia · score 0.04
- nanophthalmos 2 · score 0.04
- microphthalmia · score 0.04
- cancer · score 0.00
- laryngotracheoesophageal cleft · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3SYB3-F1 | alphafold | PREDICTED | 56.22 | — |
Amino-acid sequence (417 residues)
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC
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