2-acylglycerol O-acyltransferase 2 (MOGAT2)

About 2-acylglycerol O-acyltransferase 2

2-acylglycerol O-acyltransferase 2 (MOGAT2) is a protein from Homo sapiens identified by UniProt accession Q3SYC2, 334 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	2-acylglycerol O-acyltransferase 2
UniProt accession	Q3SYC2
Gene	MOGAT2
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.39
apolipoprotein A 1 measurement · score 0.35
alkaline phosphatase measurement · score 0.25
hematocrit · score 0.24
hemoglobin measurement · score 0.23
erythrocyte count · score 0.21
bilirubin measurement · score 0.17
phosphatidylcholine measurement · score 0.16
red blood cell density measurement · score 0.16
lysophosphatidylcholine measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3SYC2-F1	alphafold	PREDICTED	94.84	—

Amino-acid sequence (334 residues)

MVEFAPLFMP WERRLQTLAV LQFVFSFLAL AEICTVGFIA LLFTRFWLLT VLYAAWWYLD RDKPRQGGRH IQAIRCWTIW KYMKDYFPIS LVKTAELDPS RNYIAGFHPH GVLAVGAFAN LCTESTGFSS IFPGIRPHLM MLTLWFRAPF FRDYIMSAGL VTSEKESAAH ILNRKGGGNL LGIIVGGAQE ALDARPGSFT LLLRNRKGFV RLALTHGAPL VPIFSFGEND LFDQIPNSSG SWLRYIQNRL QKIMGISLPL FHGRGVFQYS FGLIPYRRPI TTVVGKPIEV QKTLHPSEEE VNQLHQRYIK ELCNLFEAHK LKFNIPADQH LEFC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards