Tubulin beta-8 chain (TUBB8)

About Tubulin beta-8 chain

Tubulin beta-8 chain (TUBB8) is a protein from Homo sapiens identified by UniProt accession Q3ZCM7, 444 residues long. MolForge cross-references it against 0 known binders and 472 disease associations.

Target properties

Protein name	Tubulin beta-8 chain
UniProt accession	Q3ZCM7
Gene	TUBB8
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (472)

Diseases linked to this target (Open Targets).

Female infertility due to fertilization defect · score 0.76
non-small cell lung carcinoma · score 0.61
breast cancer · score 0.61
breast carcinoma · score 0.60
breast neoplasm · score 0.60
neoplasm · score 0.60
gout · score 0.59
acute lymphoblastic leukemia · score 0.59
Hodgkins lymphoma · score 0.59
prostate cancer · score 0.59

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3ZCM7-F1	alphafold	PREDICTED	91.95	—

Amino-acid sequence (444 residues)

MREIVLTQIG QCGNQIGAKF WEVISDEHAI DSAGTYHGDS HLQLERINVY YNEASGGRYV PRAVLVDLEP GTMDSVRSGP FGQVFRPDNF IFGQCGAGNN WAKGHYTEGA ELMESVMDVV RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LLSKIREEYP DRIINTFSIL PSPKVSDTVV EPYNATLSVH QLIENADETF CIDNEALYDI CSKTLKLPTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVAELT QQMFDAKNMM AACDPRHGRY LTAAAIFRGR MPMREVDEQM FNIQDKNSSY FADWLPNNVK TAVCDIPPRG LKMSATFIGN NTAIQELFKR VSEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEEDEEYAE EEVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards