About Kelch repeat and BTB domain-containing protein 12
Kelch repeat and BTB domain-containing protein 12 (KBTBD12) is a protein
from Homo sapiens identified by UniProt accession
Q3ZCT8, 623 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Kelch repeat and BTB domain-containing protein 12 |
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| UniProt accession | Q3ZCT8 |
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| Gene | KBTBD12 |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- platelet count · score 0.27
- Primary amenorrhea · score 0.12
- eosinophil count · score 0.11
- musculoskeletal system disease · score 0.09
- gastric carcinoma · score 0.04
- Barrett's esophagus · score 0.03
- familial visceral myopathy · score 0.03
- Microphthalmia - ankyloblepharon - intellectual disability · score 0.03
- hypertension · score 0.02
- myelodysplastic syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3ZCT8-F1 | alphafold | PREDICTED | 90.13 | — |
Amino-acid sequence (623 residues)
MECKIEGKEK YQHSLNLLNK IQNMKELAEM IDVVLTAEGE KFPCHRLVLA AFSPYFKAMF TCGLLECNQR EVILYDITAE SVSVLLNYMY NAALEINNAN VQTVAMAAYF MQMEEVFSVC QKYMMDHMDA SNCLGIYYFA KQIGAEDLSD RSKKYLYQHF AEVSLHEEIL EIEVHQFLTL IKSDDLNISR EESILDLVLR WVNHNKELRT VHLVELLKQV RLELVNPSFL RQALRRNTML LCDADCVDII QNAFKAIKTP QQHSLNLRYG METTSLLLCI GNNSSGIRSR HRSYGDASFC YDPVSRKTYF ISSPKYGEGL GTVCTGVVME NNTIIVAGEA SASKLSRQKN KNVEIYRYHD RGNQFWEKLC TAEFRELYAL GSIHNDLYVI GGQMKIKNQY LITNCVDKYS VERDNWKRVS PLPLQLACHA VVTVNNKLYV IGGWTPQMDL PDEEPDRLSN KLLQYDPSQD QWSVRAPMKY SKYRFSTAVV NSEIYVLGGI GCVGQDKGQV RKCLDVVEIY NPDGDFWREG PPMPSPLLSL RTNSTNAGAV DGKLYVCGGF HGADRHEVIS KEILELDPWE NQWNVVAINV LMHDSYDVCL VARMNPRDLI PPPSDLVEEG NEH
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