Ciliary microtubule-associated protein 2 (CIMAP2)

About Ciliary microtubule-associated protein 2

Ciliary microtubule-associated protein 2 (CIMAP2) is a protein from Homo sapiens identified by UniProt accession Q3ZCV2, 418 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Ciliary microtubule-associated protein 2
UniProt accession	Q3ZCV2
Gene	CIMAP2
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

osteoarthritis, hand · score 0.26
visceral adipose tissue measurement · score 0.24
white matter microstructure measurement · score 0.24
phospholipid measurement · score 0.24
metabolite measurement · score 0.11
severe combined immunodeficiency due to CTPS1 deficiency · score 0.07
severe combined immunodeficiency due to CARD11 deficiency · score 0.07
immunodeficiency 18 · score 0.07
isolated agammaglobulinemia · score 0.06
Wiskott-Aldrich syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3ZCV2-F1	alphafold	PREDICTED	64.06	—

Amino-acid sequence (418 residues)

MRESQDAAGA HGWNRVGSTA TKWFTGAPFG VQSHRFDISA VYPNWKKFST FTEAPYSTRY STQVSHIGPG TYSSKETCFS KKKLMKEVDT GWAKAQEATR LTQLPHFQYQ AIMKEKRLKE QKLGPGSYNL KDFLEQLREK PCSTRGLLSS GEVRFRGLTG NYYPGPGNYG EKGNPYTKLE ENAWNRSHSE GLMCRMSNKP HPRPHQGSGL GPGTYFFKSD LETYVARSVG TRGPYDTFSG DRSKPLPYGH YSMQKKKPRE LMNFKSFVEE LNSHHNKKHG VFSKLPRNPK TPTERIYWAN LSQCPRTLAT SGPSFWLPQE KKCKPVNQPP FLLTSKGSGA KACQMIMGSW NPVGVGRYLN TWLMETKDRR QRYRSLFLSG SKRYLSDLAR DMLMQERITP FTKGKCPPTV DYNSDPTP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards