Ligand-gated cation channel ZACN (ZACN)

About Ligand-gated cation channel ZACN

Ligand-gated cation channel ZACN (ZACN) is a protein from Homo sapiens identified by UniProt accession Q401N2, 412 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Ligand-gated cation channel ZACN
UniProt accession	Q401N2
Gene	ZACN
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (9)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with seizures and brain atrophy · score 0.12
lymphocyte count · score 0.03
COVID-19 · score 0.01
IGA glomerulonephritis · score 0.01
neoplasm · score 0.00
breast cancer · score 0.00
head and neck squamous cell carcinoma · score 0.00
myelodysplastic syndrome · score 0.00
transient neonatal diabetes mellitus · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q401N2-F1	alphafold	PREDICTED	77.53	—

Amino-acid sequence (412 residues)

MMALWSLLHL TFLGFSITLL LVHGQGFQGT AAIWPSLFNV NLSKKVQESI QIPNNGSAPL LVDVRVFVSN VFNVDILRYT MSSMLLLRLS WLDTRLAWNT SAHPRHAITL PWESLWTPRL TILEALWVDW RDQSPQARVD QDGHVKLNLA LATETNCNFE LLHFPRDHSN CSLSFYALSN TAMELEFQAH VVNEIVSVKR EYVVYDLKTQ VPPQQLVPCF QVTLRLKNTA LKSIIALLVP AEALLLADVC GGLLPLRAIE RIGYKVTLLL SYLVLHSSLV QALPSSSSCN PLLIYYFTIL LLLLFLSTIE TVLLAGLLAR GNLGAKSGPS PAPRGEQREH GNPGPHPAEE PSRGVKGSQR SWPETADRIF FLVYVVGVLC TQFVFAGIWM WAACKSDAAP GEAAPHGRRP RL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards