About Dynein regulatory complex protein 12
Dynein regulatory complex protein 12 (DRC12) is a protein
from Homo sapiens identified by UniProt accession
Q494R4, 210 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Dynein regulatory complex protein 12 |
|---|
| UniProt accession | Q494R4 |
|---|
| Gene | DRC12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 210 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- platelet count · score 0.20
- mean corpuscular volume · score 0.19
- lymphocyte count · score 0.18
- calcium measurement · score 0.14
- bilirubin measurement · score 0.08
- mean corpuscular hemoglobin concentration · score 0.08
- sex hormone-binding globulin measurement · score 0.08
- monocyte count · score 0.07
- reticulocyte count · score 0.06
- platelet crit · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q494R4-F1 | alphafold | PREDICTED | 88.33 | — |
Amino-acid sequence (210 residues)
MPPKNKEKGK KSGAQKKKKN WGADVVAESR HRLVVLEKEL LRDHLALRRD EARRAKASED QLRQRLQGVE AELEGARSEG KAIYAEMSRQ CHALQEDMQT RSKQLEEEVK GLRGQLEACQ REAAAAREEA EQALGERDQA LAQLRAHMAD MEAKYEEILH DSLDRLLAKL RAIKQQWDGA ALRLHARHKE QQRQFGLTPP GSLRPPAPSL
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