About Pleckstrin homology domain-containing family N member 1
Pleckstrin homology domain-containing family N member 1 (PLEKHN1) is a protein
from Homo sapiens identified by UniProt accession
Q494U1, 611 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family N member 1 |
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| UniProt accession | Q494U1 |
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| Gene | PLEKHN1 |
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| Organism | Homo sapiens |
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| Length | 611 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.14
- mitochondrial DNA measurement · score 0.11
- alcohol consumption measurement · score 0.07
- alkaline phosphatase measurement · score 0.07
- heel bone mineral density · score 0.07
- obesity due to melanocortin 4 receptor deficiency · score 0.06
- pancreatic carcinoma · score 0.05
- obesity due to pro-opiomelanocortin deficiency · score 0.05
- apolipoprotein A 1 measurement · score 0.05
- obesity due to leptin receptor gene deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q494U1-F1 | alphafold | PREDICTED | 53.42 | — |
Amino-acid sequence (611 residues)
MGNSHCVPQA PRRLRASFSR KPSLKGNRED SARMSAGLPG PEAARSGDAA ANKLFHYIPG TDILDLENQR ENLEQPFLSV FKKGRRRVPV RNLGKVVHYA KVQLRFQHSQ DVSDCYLELF PAHLYFQAHG SEGLTFQGLL PLTELSVCPL EGSREHAFQI TGPLPAPLLV LCPSRAELDR WLYHLEKQTA LLGGPRRCHS APPQRRLTRL RTASGHEPGG SAVCASRVKL QHLPAQEQWD RLLVLYPTSL AIFSEELDGL CFKGELPLRA VHINLEEKEK QIRSFLIEGP LINTIRVVCA SYEDYGHWLL CLRAVTHREG APPLPGAESF PGSQVMGSGR GSLSSGGQTS WDSGCLAPPS TRTSHSLPES SVPSTVGCSS QHTPDQANSD RASIGRRRTE LRRSGSSRSP GSKARAEGRG PVTPLHLDLT QLHRLSLESS PDAPDHTSET SHSPLYADPY TPPATSHRRV TDVRGLEEFL SAMQSARGPT PSSPLPSVPV SVPASDPRSC SSGPAGPYLL SKKGALQSRA AQRHRGSAKD GGPQPPDAPQ LVSSAREGSP EPWLPLTDGR SPRRSRDPGY DHLWDETLSS SHQKCPQLGG PEASGGLVQW I
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