About Cilia- and flagella-associated protein 100
Cilia- and flagella-associated protein 100 (CFAP100) is a protein
from Homo sapiens identified by UniProt accession
Q494V2, 611 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 100 |
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| UniProt accession | Q494V2 |
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| Gene | CFAP100 |
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| Organism | Homo sapiens |
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| Length | 611 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (18)
Diseases linked to this target (Open Targets).
- hematocrit · score 0.08
- hemoglobin measurement · score 0.08
- hair shape measurement · score 0.07
- urate measurement · score 0.07
- alopecia · score 0.05
- uric acid measurement · score 0.05
- protein measurement · score 0.05
- drug use measurement · score 0.04
- heel bone mineral density · score 0.04
- chronic obstructive pulmonary disease · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q494V2-F1 | alphafold | PREDICTED | 73.84 | — |
Amino-acid sequence (611 residues)
MSEIPSTIVS KNMTNDKNSL ESMNISSSSS TEENPKKQAR KNEEHGPDPS ANPFHLSGDV DFFLLRDQER NKALSERQQQ KTMRVHQKMT YSSKVSAKHT SLRRQLQLED KQEDLEARAE AEHQRAFRDY TTWKLTLTKE KNVEPENMSG YIKQKRQMFL LQYALDVKRR EIQRLETLAT KEEARLERAE KSLEKDAALF DEFVRENDCS SVQAMRAAEK ETKAKIEKIL EIRDLTTQIV NIKSEISRFE DTLKHYKVYK DFLYKLSPKE WLEEQEKKHS FLKKAKEVSE ASKESSVNST PGDKGPGIKG KASSMWAKEG QGTKKPWRFL QTMRLGRSPS YLSSPQQGSQ PSESSGGDSR GSNSPIPPTQ EDTDSDGEEP QLYFTEPQQL LDVFRELEEQ NLSLIQNSQE TEKTLEELSH TLKHTQIRMD REVNQLKQWV TTMMMSITKE EDTAAELELK ARVFHFGEYK GDQQDKLLES LNCKVLDVYR HCTGTQQEAN LGTVQMLTII EHQLDELLEN LEHVPQVKIE QAERAKEKER RIRLREEKLQ MQKILQEEHL QRARARAQAE IKKKRGRTLV CRSRPPAHRI KQQSEHTLMD KEEEELLFFF T
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