CHRNA7-FAM7A fusion protein (CHRFAM7A)

About CHRNA7-FAM7A fusion protein

CHRNA7-FAM7A fusion protein (CHRFAM7A) is a protein from Homo sapiens identified by UniProt accession Q494W8, 412 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	CHRNA7-FAM7A fusion protein
UniProt accession	Q494W8
Gene	CHRFAM7A
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

Leber congenital amaurosis 10 · score 0.06
hypertriglyceridemia 2 · score 0.05
cholesterol-ester transfer protein deficiency · score 0.05
Abnormality of the ear · score 0.05
Young adult-onset Parkinsonism · score 0.05
Combined hyperlipidemia · score 0.04
thyroid hormone metabolism, abnormal, 2 · score 0.04
Absent thumb - short stature - immunodeficiency · score 0.04
Kallmann syndrome · score 0.04
renal fibrosis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q494W8-F1	alphafold	PREDICTED	68.96	—

Amino-acid sequence (412 residues)

MQKYCIYQHF QFQLLIQHLW IAANCDIADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD FA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards