Zinc finger protein 404 (ZNF404)

About Zinc finger protein 404

Zinc finger protein 404 (ZNF404) is a protein from Homo sapiens identified by UniProt accession Q494X3, 552 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Zinc finger protein 404
UniProt accession	Q494X3
Gene	ZNF404
Organism	Homo sapiens
Length	552 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.27
hemorrhoid · score 0.21
YKL40 measurement · score 0.03
inflammatory biomarker measurement · score 0.03
mean corpuscular hemoglobin concentration · score 0.02
large cell medulloblastoma · score 0.02
rosacea · score 0.01
adrenal cortex carcinoma · score 0.01
neoplasm · score 0.00
meningococcal infection · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q494X3-F1	alphafold	PREDICTED	73.61	—

Amino-acid sequence (552 residues)

MARVPLTFSD VAIDFSQEEW EYLNSDQRDL YRDVMLENYT NLVSLDFNFT TESNKLSSEK RNYEVNAYHQ ETWKRNKTFN LMRFIFRTDP QYTIEFGRQQ RPKVGCFSQM IFKKHKSLPL HKRNNTREKS YECKEYKKGF RKYLHLTEHL RDHTGVIPYE CNECGKAFVV FQHFIRHRKI HTDLKPYECN GCEKAFRFYS QLIQHQIIHT GMKPYECKQC GKAFRRHSHL TEHQKIHVGL KPFECKECGE TFRLYRHMCL HQKIHHGVKP YKCKECGKAF GHRSSLYQHK KIHSGEKPYK CEQCEKAFVR SYLLVEHQRS HTGEKPHECM ECGKAFGKGS SLLKHKRIHS SEKLYDCKDC GKAFCRGSQL TQHQRIHTGE KPHECKECGK TFKLHSYLIQ HQIIHTDLKP YECKQCGKAF SRVGDLKTHQ SIHAGEKPYE CKECGKTFRL NSQLIYHQTI HTGLKPYVCK ECKKAFRSIS GLSQHKRIHT GEKPYECKEC DKAFNRSDRL TQHETIHTGV KPQKCKECGK AFSHCYQLSQ HQRFHHGERL LM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards