About T-cell immunoreceptor with Ig and ITIM domains
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a protein
from Homo sapiens identified by UniProt accession
Q495A1, 244 residues long.
MolForge cross-references it against 0 known binders and
378 disease associations.
Target properties
| Protein name | T-cell immunoreceptor with Ig and ITIM domains |
|---|
| UniProt accession | Q495A1 |
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| Gene | TIGIT |
|---|
| Organism | Homo sapiens |
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| Length | 244 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (378)
Diseases linked to this target (Open Targets).
- non-small cell lung carcinoma · score 0.41
- cancer · score 0.37
- small cell lung carcinoma · score 0.37
- neurodegenerative disease · score 0.33
- melanoma · score 0.32
- hepatocellular carcinoma · score 0.31
- esophageal squamous cell carcinoma · score 0.29
- adenocarcinoma · score 0.26
- esophageal cancer · score 0.26
- lung neoplasm · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q495A1-F1 | alphafold | PREDICTED | 74.60 | — |
Amino-acid sequence (244 residues)
MRWCLLLIWA QGLRQAPLAS GMMTGTIETT GNISAEKGGS IILQCHLSST TAQVTQVNWE QQDQLLAICN ADLGWHISPS FKDRVAPGPG LGLTLQSLTV NDTGEYFCIY HTYPDGTYTG RIFLEVLESS VAEHGARFQI PLLGAMAATL VVICTAVIVV VALTRKKKAL RIHSVEGDLR RKSAGQEEWS PSAPSPPGSC VQAEAAPAGL CGEQRGEDCA ELHDYFNVLS YRSLGNCSFF TETG
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