About Ankyrin repeat and death domain-containing protein 1A
Ankyrin repeat and death domain-containing protein 1A (ANKDD1A) is a protein
from Homo sapiens identified by UniProt accession
Q495B1, 522 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Ankyrin repeat and death domain-containing protein 1A |
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| UniProt accession | Q495B1 |
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| Gene | ANKDD1A |
|---|
| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- platelet count · score 0.33
- platelet component distribution width · score 0.30
- mean platelet volume · score 0.24
- body height · score 0.09
- platelet crit · score 0.08
- breast cancer · score 0.07
- pulse pressure measurement · score 0.07
- FEV/FVC ratio · score 0.07
- glioblastoma multiforme · score 0.07
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q495B1-F1 | alphafold | PREDICTED | 89.70 | — |
Amino-acid sequence (522 residues)
MQEELAWETD GLLPLERQLH EAARQNNVGR MQELIGRRVN TRARNHVGRV ALHWAAGAGH EQAVRLLLEH EAAVDEEDAV GALTEARLCF GMNALLLSAW FGHLRILQIL VNSGAKIHCE SKDGLTLLHC AAQKGHVPVL AFIMEDLEDV ALDHVDKLGR TAFHRAAEHG QLDALDFLVG SGCDHNVKDK EGNTALHLAA GRGHMAVLQR LVDIGLDLEE QNAEGLTALH SAAGGSHPDC VQLLLRAGST VNALTQKNLS CLHYAALSGS EDVSRVLIHA GGCANVVDHQ GASPLHLAVR HNFPALVRLL INSDSDVNAV DNRQQTPLHL AAEHAWQDIA DMLLIAGVDL NLRDKQGKTA LAVAVRSNHV SLVDMIIKAD RFYRWEKDHP SDPSGKSLSF KQDHRQETQQ LRSVLWRLAS RYLQPREWKK LAYSWEFTEA HVDAIEQQWT GTRSYQEHGH RMLLIWLHGV ATAGENPSKA LFEGLVAIGR RDLAGWSTMA RSQLTATSAS RVQMILVPQP PE
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