Probable E3 SUMO-protein ligase RNF212 (RNF212)

About Probable E3 SUMO-protein ligase RNF212

Probable E3 SUMO-protein ligase RNF212 (RNF212) is a protein from Homo sapiens identified by UniProt accession Q495C1, 297 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	Probable E3 SUMO-protein ligase RNF212
UniProt accession	Q495C1
Gene	RNF212
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.39
bone quantitative ultrasound measurement · score 0.37
recombination rate · score 0.34
heel bone mineral density · score 0.32
bone density · score 0.28
Down syndrome · score 0.19
Immature Reticulocyte Fraction Measurement · score 0.18
azoospermia · score 0.14
breast ductal adenocarcinoma · score 0.11
blood protein measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q495C1-F1	alphafold	PREDICTED	62.96	—

Amino-acid sequence (297 residues)

MANWVFCNRC FQPPHRTSCF SLTNCGHVYC DACLGKGKKN ECLICKAPCR TVLLSKHTDA DIQAFFMSID SLCKKYSRET SQILEFQEKH RKRLLAFYRE KISRLEESLR KSVLQIEQLQ SMRSSQQTAF STIKSSVSTK PHGCLLPPHS SAPDRLESME VDLSPSPIRK SEIAAGPARI SMISPPQDGR MGPHLTASFC FIPWLTLSKP PVPGECVISR GSPCFCIDVC PHWLLLLAFS SGRHGELTNS KTLPIYAEVQ RAVLFPFQQA EGTLDTFRTP AVSVVFPLCQ FERKKSF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards