Proton-coupled amino acid transporter 2 (SLC36A2)

About Proton-coupled amino acid transporter 2

Proton-coupled amino acid transporter 2 (SLC36A2) is a protein from Homo sapiens identified by UniProt accession Q495M3, 483 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Proton-coupled amino acid transporter 2
UniProt accession	Q495M3
Gene	SLC36A2
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

iminoglycinuria · score 0.49
Sensorineural hearing impairment · score 0.37
pyroglutamine measurement · score 0.24
Hyperglycinuria · score 0.23
adolescent idiopathic scoliosis · score 0.06
basophil count · score 0.03
infection · score 0.03
infect · score 0.03
basophil percentage of leukocytes · score 0.02
bronchopulmonary dysplasia · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q495M3-F1	alphafold	PREDICTED	84.05	—

Amino-acid sequence (483 residues)

MSVTKSTEGP QGAVAIKLDL MSPPESAKKL ENKDSTFLDE SPSESAGLKK TKGITVFQAL IHLVKGNMGT GILGLPLAVK NAGILMGPLS LLVMGFIACH CMHILVKCAQ RFCKRLNKPF MDYGDTVMHG LEANPNAWLQ NHAHWGRHIV SFFLIITQLG FCCVYIVFLA DNLKQVVEAV NSTTNNCYSN ETVILTPTMD SRLYMLSFLP FLVLLVLIRN LRILTIFSML ANISMLVSLV IIIQYITQEI PDPSRLPLVA SWKTYPLFFG TAIFSFESIG VVLPLENKMK NARHFPAILS LGMSIVTSLY IGMAALGYLR FGDDIKASIS LNLPNCWLYQ SVKLLYIAGI LCTYALQFYV PAEIIIPFAI SRVSTRWALP LDLSIRLVMV CLTCLLAILI PRLDLVISLV GSVSGTALAL IIPPLLEVTT FYSEGMSPLT IFKDALISIL GFVGFVVGTY QALDELLKSE DSHPFSNSTT FVR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards