pre-mRNA splicing regulator USH1G (USH1G)

About pre-mRNA splicing regulator USH1G

pre-mRNA splicing regulator USH1G (USH1G) is a protein from Homo sapiens identified by UniProt accession Q495M9, 461 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	pre-mRNA splicing regulator USH1G
UniProt accession	Q495M9
Gene	USH1G
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

Usher syndrome type 1 · score 0.68
Usher syndrome · score 0.55
deafness · score 0.48
Hearing impairment · score 0.43
hearing loss · score 0.37
hearing loss, autosomal recessive · score 0.32
Rare genetic deafness · score 0.27
genetic disorder · score 0.19
autism · score 0.08
Asperger syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q495M9-F1	alphafold	PREDICTED	68.25	—

Amino-acid sequence (461 residues)

MNDQYHRAAR DGYLELLKEA TRKELNAPDE DGMTPTLWAA YHGNLESLRL IVSRGGDPDK CDIWGNTPLH LAASNGHLHC LSFLVSFGAN IWCLDNDYHT PLDMAAMKGH MECVRYLDSI AAKQSSLNPK LVGKLKDKAF REAERRIREC AKLQRRHHER MERRYRRELA ERSDTLSFSS LTSSTLSRRL QHLALGSHLP YSQATLHGTA RGKTKMQKKL ERRKQGGEGT FKVSEDGRKS ARSLSGLQLG SDVMFVRQGT YANPKEWGRA PLRDMFLSDE DSVSRATLAA EPAHSEVSTD SGHDSLFTRP GLGTMVFRRN YLSSGLHGLG REDGGLDGVG APRGRLQSSP SLDDDSLGSA NSLQDRSCGE ELPWDELDLG LDEDLEPETS PLETFLASLH MEDFAALLRQ EKIDLEALML CSDLDLRSIS VPLGPRKKIL GAVRRRRQAM ERPPALEDTE L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards