GDP-fucose protein O-fucosyltransferase 4 (POFUT4)

About GDP-fucose protein O-fucosyltransferase 4

GDP-fucose protein O-fucosyltransferase 4 (POFUT4) is a protein from Homo sapiens identified by UniProt accession Q495W5, 492 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	GDP-fucose protein O-fucosyltransferase 4
UniProt accession	Q495W5
Gene	POFUT4
Organism	Homo sapiens
Length	492 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

vital capacity · score 0.17
total blood protein measurement · score 0.16
forced expiratory volume · score 0.14
atrial fibrillation · score 0.11
atrial flutter · score 0.10
systolic blood pressure · score 0.09
myocardial infarction · score 0.09
C-reactive protein measurement · score 0.08
gonorrhea · score 0.08
self reported educational attainment · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q495W5-F1	alphafold	PREDICTED	85.31	—

Amino-acid sequence (492 residues)

MAAGPIRVVL VLLGVLSVCA ASGHGSVAER EAGGEAEWAE PWDGAVFRPP SALGAVGVTR SSGTPRPGRE EAGDLPVLLW WSPGLFPHFP GDSERIECAR GACVASRNRR ALRDSRTRAL LFYGTDFRAS AAPLPRLAHQ SWALLHEESP LNNFLLSHGP GIRLFNLTST FSRHSDYPLS LQWLPGTAYL RRPVPPPMER AEWRRRGYAP LLYLQSHCDV PADRDRYVRE LMRHIPVDSY GKCLQNRELP TARLQDTATA TTEDPELLAF LSRYKFHLAL ENAICNDYMT EKLWRPMHLG AVPVYRGSPS VRDWMPNNHS VILIDDFESP QKLAEFIDFL DKNDEEYMKY LAYKQPGGIT NQFLLDSLKH REWGVNDPLL PNYLNGFECF VCDYELARLD AEKAHAASPG DSPVFEPHIA QPSHMDCPVP TPGFGNVEEI PENDSWKEMW LQDYWQGLDQ GEALTAMIHN NETEQTKFWD YLHEIFMKRQ HL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards