Inactive serine/threonine-protein kinase PLK5 (PLK5)

About Inactive serine/threonine-protein kinase PLK5

Inactive serine/threonine-protein kinase PLK5 (PLK5) is a protein from Homo sapiens identified by UniProt accession Q496M5, 336 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Inactive serine/threonine-protein kinase PLK5
UniProt accession	Q496M5
Gene	PLK5
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

breast ductal adenocarcinoma · score 0.11
neoplasm · score 0.08
non-small cell lung carcinoma · score 0.08
nonpapillary renal cell carcinoma · score 0.03
cancer · score 0.03
Urinary retention · score 0.02
response to radiation · score 0.02
inflammatory breast carcinoma · score 0.01
glioblastoma multiforme · score 0.01
Thymoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q496M5-F1	alphafold	PREDICTED	68.07	—

Amino-acid sequence (336 residues)

MYTVLTGTPP FMASPLSEMY QNIREGHYPE PAHLSANARR LIVHLLAPNP AERPSLDHLL QDDFFTQGFT PDRLPAHSCH SPPIFAIPPP LGRIFRKVGQ RLLTQCRPPC PFTPKEASGP GEGGPDPDSM EWDGESSLSA KEVPCLEGPI HLVAQGTLQS DLAGPEGSRR PEVEAALRHL QLCLDVGPPA TQDPLGEQQP ILWAPKWVDY SSKYGFGYQL LDGGRTGRHP HGPATPRREG TLPTPVPPAG PGLCLLRFLA SEHALLLLFS NGMVQVSFSG VPAQLVLSGE GEGLQLTLWE QGSPGTSYSL DVPRSHGCAP TTGQHLHHAL RMLQSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards