About LON peptidase N-terminal domain and RING finger protein 3
LON peptidase N-terminal domain and RING finger protein 3 (LONRF3) is a protein
from Homo sapiens identified by UniProt accession
Q496Y0, 759 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | LON peptidase N-terminal domain and RING finger protein 3 |
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| UniProt accession | Q496Y0 |
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| Gene | LONRF3 |
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| Organism | Homo sapiens |
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| Length | 759 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- Autosomal dominant primary hypomagnesemia with hypocalciuria · score 0.06
- Primary hypomagnesemia with secondary hypocalcemia · score 0.06
- hypoparathyroidism, familial isolated, 2 · score 0.06
- familial isolated hyperparathyroidism · score 0.06
- hyperparathyroidism · score 0.06
- blue diaper syndrome · score 0.05
- pseudohypoparathyroidism type 2 · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- adamantinoma · score 0.04
- Familial isolated hypoparathyroidism · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q496Y0-F1 | alphafold | PREDICTED | 73.80 | — |
Amino-acid sequence (759 residues)
MESVRIEQML SLPAEVSSDN LESAERGASA AQVDMGPHPK VAAEGPAPLP TREPEQEQSP GTSTPESKVL LTQADALASR GRIREALEVY RQLSERQQLV AEQLEQLVRC LAEKVPQGEA LAPAPPDEGS TASGTVAAEE TGAAAAAAAT EVWDGFKCRK CHGFLSDPVS LSCGHTFCKL CLERGRAADR RCALCGVKLS ALMVATGRAR GARRAGQQPP PPLRVNVVLS GLLGKLFPGP ARASQLRHEG NRLYRERQVE AALLKYNEAV KLAPNDHLLY SNRSQIYFTL ESHENALHDA EIACKLRPMG FKAHFRKAQA LATLGKVEEA LREFLYCVSL DGKNKRARCE AQRDNLELPH CSSQEEAAAR GDGSSLMDPA KVKGDGQQHH MKDQEEEEEK WDATSPKAAS SKTGKCQEKK RKHCQIESQE ETGMPNKASK QDPPTDQGDK PALSLPLASF DASDLECALC MRLFYEPVTT PCGHTFCLKC LERCLDHNAK CPLCKDGLSQ CLASRKYSKN VIMEELIAKF LPEELKERRK LYEEEMEELS NLNKNVPIFV CTMAYPTVPC PLHIFEPCYR LMIRRCIETG TRQFGMCLGD PVKGFAEYGC ILEIRNVQFF ADGRSVVDSI GKRRFRVLHQ SQRDGYNTAD IEYIEDQKVQ GEDCAELMGL HNCVYQQASL WFHSLKLSLK NRILNHFGPM PEKDADPQMN PNGPAWCWWM LAVLPLESRA QLPFLAMRSL KDRLNGIRRV LAFISRNQN
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