About Coiled-coil domain-containing protein 14
Coiled-coil domain-containing protein 14 (CCDC14) is a protein
from Homo sapiens identified by UniProt accession
Q49A88, 953 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 14 |
|---|
| UniProt accession | Q49A88 |
|---|
| Gene | CCDC14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 953 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- intelligence · score 0.30
- self reported educational attainment · score 0.25
- systemic lupus erythematosus · score 0.04
- marginal zone B-cell lymphoma · score 0.03
- diffuse large B-cell lymphoma · score 0.03
- mathematical ability · score 0.03
- cognitive function measurement · score 0.02
- platelet-to-lymphocyte ratio · score 0.02
- Pick disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q49A88-F1 | alphafold | PREDICTED | 56.80 | — |
Amino-acid sequence (953 residues)
MKRGIRRDPF RKRKLGGRAK KVREPTAVNS FYREASLPSV WASLRRREMV RSGARPGQVL SSGRHTGPAK LTNGKKATYL RKIPRFNADS GYSIHSDSES QAETVHGLDG CASLLRDILR NEDSGSETAY LENRSNSRPL ESKRYGSKKK RHEKHTIPLV VQKETSSSDN KKQIPNEASA RSERDTSDLE QNWSLQDHYR MYSPIIYQAL CEHVQTQMSL MNDLTSKNIP NGIPAVPCHA PSHSESQATP HSSYGLCTST PVWSLQRPPC PPKVHSEVQT DGNSQFASQG KTVSATCTDV LRNSFNTSPG VPCSLPKTDI SAIPTLQQLG LVNGILPQQG IHKETDLLKC IQTYLSLFRS HGKETHLDSQ THRSPTQSQP AFLATNEEKC AREQIREATS ERKDLNIHVR DTKTVKDVQK AKNVNKTAEK VRIIKYLLGE LKALVAEQED SEIQRLITEM EACISVLPTV SGNTDIQVEI ALAMQPLRSE NAQLRRQLRI LNQQLREQQK TQKPSGAVDC NLELFSLQSL NMSLQNQLEE SLKSQELLQS KNEELLKVIE NQKDENKKFS SIFKDKDQTI LENKQQYDIE ITRIKIELEE ALVNVKSSQF KLETAEKENQ ILGITLRQRD AEVTRLRELT RTLQTSMAKL LSDLSVDSAR CKPGNNLTKS LLNIHDKQLQ HDPAPAHTSI MSYLNKLETN YSFTHSEPLS TIKNEETIEP DKTYENVLSS RGPQNSNTRG MEEASAPGII SALSKQDSDE GSETMALIED EHNLDNTIYI PFARSTPEKK SPLSKRLSPQ PQIRAATTQL VSNSGLAVSG KENKLCTPVI CSSSTKEAED APEKLSRASD MKDTQLLKKI KEAIGKIPAA TKEPEEQTAC HGPSGCLSNS LQVKGNTVCD GSVFTSDLMS DWSISSFSTF TSRDEQDFRN GLAALDANIA RLQKSLRTGL LEK
Explore Coiled-coil domain-containing protein 14 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets