Uncharacterized protein C8orf34 (C8orf34)

About Uncharacterized protein C8orf34

Uncharacterized protein C8orf34 (C8orf34) is a protein from Homo sapiens identified by UniProt accession Q49A92, 538 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Uncharacterized protein C8orf34
UniProt accession	Q49A92
Gene	C8orf34
Organism	Homo sapiens
Length	538 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.42
vital capacity · score 0.42
musculoskeletal system disease · score 0.34
forced expiratory volume · score 0.31
alcohol consumption measurement · score 0.31
diffuse plaque measurement · score 0.31
coronary artery disease · score 0.30
childhood trauma measurement · score 0.29
waist-hip ratio · score 0.28
Back pain · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q49A92-F1	alphafold	PREDICTED	56.64	—

Amino-acid sequence (538 residues)

MSSPLASELS ELAALRPGFR LSAPHARVAP RAATHARGRG RASHAGQPRL RSSCPGPSPG KRRVVPSGGA QPRVLPALSS RSHLFPMASH PQTRIQAYLE KNKIGPLFEE LMTKLITETP DQPIPFLIDH LQSKQGNRGQ LQRTLSGSAA LWAESEKSES KGTRRDFRSY DKPWQLNAKK PKKSKSDLAV SNISPPSPDS KSLPRSVEHP KWNWRTKPQS RDFDELNHIL QESKKLGKAL ENLSRSIAIS DELDKETVTF NSSLLRPRVI GEWIGREEND ADPLAAEMLQ PPIPRSKNDQ WESEDSGSSP AGSLKMEPKN KGLKQQQQQH KKLLAAMLSQ DSFESIHSPT PSVTEEDIDN EDDAMELLED LNDLRMEGVT TLVPSGSKFN QGRPTYPAEP QAKVTLNICS RCARLQGDNL EERTEESLPI LHSPDEKIPD SFDSLPGTEE ALMEEGDEFE KASKLTGPGE ASSGVGHSLK NYMEEDESLK QLQVVHQPWI LPSDTESEGV EAEQEKRSAD LLLCVPCSSC PTLVYSGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards