About Cerebral dopamine neurotrophic factor
Cerebral dopamine neurotrophic factor (CDNF) is a protein
from Homo sapiens identified by UniProt accession
Q49AH0, 187 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Cerebral dopamine neurotrophic factor |
|---|
| UniProt accession | Q49AH0 |
|---|
| Gene | CDNF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 187 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.41
- neurodegenerative disease · score 0.32
- lymphocyte count · score 0.17
- PHF-tau measurement · score 0.14
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.08
- protein measurement · score 0.08
- retinitis pigmentosa · score 0.08
- Familial exudative vitreoretinopathy · score 0.07
- Huntington disease · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q49AH0-F1 | alphafold | PREDICTED | 79.80 | — |
Amino-acid sequence (187 residues)
MWCASPVAVV AFCAGLLVSH PVLTQGQEAG GRPGADCEVC KEFLNRFYKS LIDRGVNFSL DTIEKELISF CLDTKGKENR LCYYLGATKD AATKILSEVT RPMSVHMPAM KICEKLKKLD SQICELKYEK TLDLASVDLR KMRVAELKQI LHSWGEECRA CAEKTDYVNL IQELAPKYAA THPKTEL
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