About Transcription termination factor 2, mitochondrial
Transcription termination factor 2, mitochondrial (MTERF2) is a protein
from Homo sapiens identified by UniProt accession
Q49AM1, 385 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Transcription termination factor 2, mitochondrial |
|---|
| UniProt accession | Q49AM1 |
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| Gene | MTERF2 |
|---|
| Organism | Homo sapiens |
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| Length | 385 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (29)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.19
- body height · score 0.19
- heel bone mineral density · score 0.11
- alkaline phosphatase measurement · score 0.11
- femoral neck bone mineral density · score 0.08
- base metabolic rate measurement · score 0.08
- bone density · score 0.07
- body weight · score 0.06
- fat body mass · score 0.06
- whole body water mass · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q49AM1-F1 | alphafold | PREDICTED | 85.26 | — |
Amino-acid sequence (385 residues)
MLWKLLLRSQ SCRLCSFRKM RSPPKYRPFL ACFTYTTDKQ SSKENTRTVE KLYKCSVDIR KIRRLKGWVL LEDETYVEEI ANILQELGAD ETAVASILER CPEAIVCSPT AVNTQRKLWQ LVCKNEEELI KLIEQFPESF FTIKDQENQK LNVQFFQELG LKNVVISRLL TAAPNVFHNP VEKNKQMVRI LQESYLDVGG SEANMKVWLL KLLSQNPFIL LNSPTAIKET LEFLQEQGFT SFEILQLLSK LKGFLFQLCP RSIQNSISFS KNAFKCTDHD LKQLVLKCPA LLYYSVPVLE ERMQGLLREG ISIAQIRETP MVLELTPQIV QYRIRKLNSS GYRIKDGHLA NLNGSKKEFE ANFGKIQAKK VRPLFNPVAP LNVEE
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