About Cryptochrome-2
Cryptochrome-2 (CRY2) is a protein
from Homo sapiens identified by UniProt accession
Q49AN0, 593 residues long.
MolForge cross-references it against 0 known binders and
153 disease associations.
Target properties
| Protein name | Cryptochrome-2 |
|---|
| UniProt accession | Q49AN0 |
|---|
| Gene | CRY2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 593 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (153)
Diseases linked to this target (Open Targets).
- fasting blood glucose measurement · score 0.42
- type 2 diabetes mellitus · score 0.38
- glucose measurement · score 0.36
- sex hormone-binding globulin measurement · score 0.34
- Alzheimer disease · score 0.29
- BMI-adjusted fasting blood glucose measurement · score 0.28
- body mass index · score 0.27
- fasting blood insulin measurement · score 0.25
- HOMA-B · score 0.25
- traffic air pollution measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q49AN0-F1 | alphafold | PREDICTED | 84.20 | — |
Amino-acid sequence (593 residues)
MAATVATAAA VAPAPAPGTD SASSVHWFRK GLRLHDNPAL LAAVRGARCV RCVYILDPWF AASSSVGINR WRFLLQSLED LDTSLRKLNS RLFVVRGQPA DVFPRLFKEW GVTRLTFEYD SEPFGKERDA AIMKMAKEAG VEVVTENSHT LYDLDRIIEL NGQKPPLTYK RFQAIISRME LPKKPVGLVT SQQMESCRAE IQENHDETYG VPSLEELGFP TEGLGPAVWQ GGETEALARL DKHLERKAWV ANYERPRMNA NSLLASPTGL SPYLRFGCLS CRLFYYRLWD LYKKVKRNST PPLSLFGQLL WREFFYTAAT NNPRFDRMEG NPICIQIPWD RNPEALAKWA EGKTGFPWID AIMTQLRQEG WIHHLARHAV ACFLTRGDLW VSWESGVRVF DELLLDADFS VNAGSWMWLS CSAFFQQFFH CYCPVGFGRR TDPSGDYIRR YLPKLKAFPS RYIYEPWNAP ESIQKAAKCI IGVDYPRPIV NHAETSRLNI ERMKQIYQQL SRYRGLCLLA SVPSCVEDLS HPVAEPSSSQ AGSMSSAGPR PLPSGPASPK RKLEAAEEPP GEELSKRARV AELPTPELPS KDA
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