About Ceramide kinase-like protein
Ceramide kinase-like protein (CERKL) is a protein
from Homo sapiens identified by UniProt accession
Q49MI3, 558 residues long.
MolForge cross-references it against 0 known binders and
267 disease associations.
Target properties
| Protein name | Ceramide kinase-like protein |
|---|
| UniProt accession | Q49MI3 |
|---|
| Gene | CERKL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 558 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (267)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.76
- Retinal dystrophy · score 0.62
- neurodegenerative disease · score 0.54
- Cone rod dystrophy · score 0.51
- autosomal recessive retinitis pigmentosa · score 0.50
- cone-rod dystrophy · score 0.49
- maturity-onset diabetes of the young type 6 · score 0.46
- cone dystrophy · score 0.43
- Retinal pigment epithelial atrophy · score 0.43
- Posterior column ataxia - retinitis pigmentosa · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q49MI3-F1 | alphafold | PREDICTED | 79.70 | — |
Amino-acid sequence (558 residues)
MPWRRRRNRV SALEGGREEE APPEAAAVPP ALLTSPQQTE AAAERILLRG IFEIGRDSCD VVLSERALRW RPIQPERPAG DSKYDLLCKE EFIELKDIFS VKLKRRCSVK QQRSGTLLGI TLFICLKKEQ NKLKNSTLDL INLSEDHCDI WFRQFKKILA GFPNRPKSLK ILLNPQSHKK EATQVYYEKV EPLLKLAGIK TDVTIMEYEG HALSLLKECE LQGFDGGHRK PLFAIHWSVQ RLFTGMQTLE PSVVCVGGDG SASEVAHALL LRAQKNAGME TDRILTPVRA QLPLGLIPAG STNVLAHSLH GVPHVITATL HIIMGHVQLV DVCTFSTAGK LLRFGFSAMF GFGGRTLALA EKYRWMSPNQ RRDFAVVKAL AKLKAEDCEI SFLPFNSSDD VQERRAQGSP KSDCNDQWQM IQGQFLNVSI MAIPCLCSVA PRGLAPNTRL NNGSMALIIA RNTSRPEFIK HLKRYASVKN QFNFPFVETY TVEEVKVHPR NNTGGYNPEE EEDETASENC FPWNVDGDLM EVASEVHIRL HPRLISLYGG SMEEMIPK
Explore Ceramide kinase-like protein with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets