Probable G-protein coupled receptor 33 (GPR33)

About Probable G-protein coupled receptor 33

Probable G-protein coupled receptor 33 (GPR33) is a protein from Homo sapiens identified by UniProt accession Q49SQ1, 333 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 33
UniProt accession	Q49SQ1
Gene	GPR33
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (11)

Diseases linked to this target (Open Targets).

epidermolysis bullosa simplex with nail dystrophy · score 0.11
Benign familial chorea · score 0.07
lymphocyte count · score 0.07
Ataxia - oculomotor apraxia type 1 · score 0.05
early-onset generalized limb-onset dystonia · score 0.05
Tourette syndrome · score 0.02
obsessive-compulsive disorder · score 0.02
neoplasm · score 0.00
Nail dystrophy · score 0.00
multiple epiphyseal dysplasia · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q49SQ1-F1	alphafold	PREDICTED	87.58	—

Amino-acid sequence (333 residues)

MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY LWVLRFKMKQ TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL FVGENFKKVF KKSILALFES TFSEDSSVER TQT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards