About Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 (ACCSL) is a protein
from Homo sapiens identified by UniProt accession
Q4AC99, 568 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 |
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| UniProt accession | Q4AC99 |
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| Gene | ACCSL |
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| Organism | Homo sapiens |
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| Length | 568 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.25
- systolic blood pressure · score 0.19
- body fat percentage · score 0.04
- serum alanine aminotransferase measurement · score 0.04
- high density lipoprotein cholesterol measurement · score 0.04
- sex hormone-binding globulin measurement · score 0.04
- low density lipoprotein triglyceride measurement · score 0.04
- aspartate aminotransferase measurement · score 0.04
- age at onset · score 0.03
- Alzheimer disease · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4AC99-F1 | alphafold | PREDICTED | 84.05 | — |
Amino-acid sequence (568 residues)
MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR QGLSLEERRH TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED SRGDVRYGQR AQLSGQPDPV PQLSDCEAAF VNRDLSIRGI DISVFYQSSF QDYNAYQKDK YHKDKNTLGF INLGTSENKL CMDLMTERLQ ESDMNCIEDT LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN GCCSVFCALA MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR YNLHVIIDEI YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS GFRFGALYTH NKEVASAVSA FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL PTNCYRLREA HKYITAELKA LEIPFHNRSS GLYVWINLKK YLDPCTFEEE RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK LAMRRFCDVL QEQKEALIVK QLEDAMRE
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