tRNA-queuosine alpha-mannosyltransferase (QTMAN)

About tRNA-queuosine alpha-mannosyltransferase

tRNA-queuosine alpha-mannosyltransferase (QTMAN) is a protein from Homo sapiens identified by UniProt accession Q4AE62, 458 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	tRNA-queuosine alpha-mannosyltransferase
UniProt accession	Q4AE62
Gene	QTMAN
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.42
cognitive function measurement · score 0.37
Oral ulcer · score 0.30
ulcer disease · score 0.29
mean corpuscular hemoglobin concentration · score 0.16
mean corpuscular volume · score 0.15
mean corpuscular hemoglobin · score 0.15
schizophrenia · score 0.14
erythrocyte count · score 0.14
body weight · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4AE62-F1	alphafold	PREDICTED	82.35	—

Amino-acid sequence (458 residues)

MSILIIEAFY GGSHKQLVDL LQEELGDCVV YTLPAKKWHW RARTSALYFS QTIPISEHYR TLFASSVLNL TELAALRPDL GKLKKILYFH ENQLIYPVKK CQERDFQYGY NQILSCLVAD VVVFNSVFNM ESFLTSMGKF MKLIPDHRPK DLESIIRPKC QVIYFPIRFP DVSRFMPKHK TTHLKKMLGL KGNGGAVLSM ALPFQPEQRD SEDLLKNFNS ECDTHCGLDT ARQEYLGNSL RQESDLKKST SSDNSSSHHG ENKQNLTVDP CDILGGVDNQ QRLLHIVWPH RWEHDKDPES FFKVLMHLKD LGLNFHVSVL GETFTDVPDI FSEAKKALGS SVLHWGYLPS KDDYFQVLCM ADVVISTAKH EFFGVAMLEA VYCGCYPLCP KDLVYPEIFP AEYLYSTPEQ LSKRLQNFCK RPDIIRKHLY KGEIAPFSWA ALHGKFRSLL TTEPREDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards