About Heat shock factor protein 5
Heat shock factor protein 5 (HSF5) is a protein
from Homo sapiens identified by UniProt accession
Q4G112, 596 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Heat shock factor protein 5 |
|---|
| UniProt accession | Q4G112 |
|---|
| Gene | HSF5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 596 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- refractive error · score 0.13
- Aplastic anemia · score 0.10
- anemia (phenotype) · score 0.10
- lung adenocarcinoma · score 0.07
- body height · score 0.07
- hypertension · score 0.06
- mean corpuscular hemoglobin concentration · score 0.06
- age at first birth measurement · score 0.06
- Familial short QT syndrome · score 0.05
- Romano-Ward syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4G112-F1 | alphafold | PREDICTED | 52.81 | — |
Amino-acid sequence (596 residues)
MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL LSPPGPGGGG GTAGAGAEPE LFKTTSFTSF IRQLNLYGFR KVVLGGPGGG KPAGNGPLHH FHNPHFRRDQ PQLLVHLKRL TSANKAKLAA GLEVPCRPPN RFQRLLITSA SAATAPLQHQ QPPPPAGPRP EPHGPVAVGQ FHRSFRRDSL SPYSCVSTPS HDHSTYPLKG LDRTPVPHRI WQNSLGMHPG QVETSPTFSD KGVPFPVLQR FPTEVTYTLQ PSTTSVHVQQ GPQTMVSSSQ KYSNYTPSAQ YSQAYYPTAV LQCCSPTHMD ALSSCVTPTA SSYAHCNYFQ NPSMQSSYPV EFLPSNWPCS TTDENTKTEV NLEAVFQIVD ELHSSPKLEM VKVEPVENQC PTSPSYRGQH ILANSNNSNP CSASQASQLE PLTPVGSDIM SFVVGTEQAV ACSLPQSPEY IYTIHTAQPV ENSTIQESAA IQQAHVKLKE HLNHNPSPSS VVFVQEGPPF STHQVDANIK CQTSSRENIL PSEQMGFLIS EMGPASKPSE DTGLATPARY REHRSNSQQG KSPDLHLLVD VACKQERFPK EEELKE
Explore Heat shock factor protein 5 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets