Glucoside xylosyltransferase 1 (GXYLT1)

About Glucoside xylosyltransferase 1

Glucoside xylosyltransferase 1 (GXYLT1) is a protein from Homo sapiens identified by UniProt accession Q4G148, 440 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Glucoside xylosyltransferase 1
UniProt accession	Q4G148
Gene	GXYLT1
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.26
HbA1c measurement · score 0.23
response to sulfonylurea · score 0.23
refractive error · score 0.20
blood urea nitrogen measurement · score 0.15
Brugada syndrome · score 0.08
familial atrial fibrillation · score 0.07
Familial progressive cardiac conduction defect · score 0.07
atrioventricular dissociation · score 0.07
familial sick sinus syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4G148-F1	alphafold	PREDICTED	83.81	—

Amino-acid sequence (440 residues)

MRRYLRVVVL CVACGFCSLL YAFSQLAVSL EEGTGGGGGK PQAAVASWLA GGGRGAVRGA GVAGPAAHPG VSDRCKDFSL CYWNPYWMLP SDVCGMNCFW EAAFRYSLKI QPVEKMHLAV VACGERLEET MTMLKSAIIF SIKPLQFHIF AEDQLHHSFK GRLDNWSFLQ TFNYTLYPIT FPSENAAEWK KLFKPCASQR LFLPLILKEV DSLLYVDTDI LFLRPVDDIW SLLKKFNSTQ IAAMAPEHEE PRIGWYNRFA RHPYYGKTGV NSGVMLMNMT RMRRKYFKND MTTVRLQWGD ILMPLLKKYK LNITWGDQDL LNIVFFHNPE SLFVFPCQWN YRPDHCIYGS NCQEAEEGGI FILHGNRGVY HDDKQPAFRA VYEALRNCSF EDDNIRSLLK PLELELQKTV HTYCGKIYKI FIKQLAKSVR DRYARSPKEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards