About Malonate--CoA ligase ACSF3, mitochondrial
Malonate--CoA ligase ACSF3, mitochondrial (ACSF3) is a protein
from Homo sapiens identified by UniProt accession
Q4G176, 576 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Malonate--CoA ligase ACSF3, mitochondrial |
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| UniProt accession | Q4G176 |
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| Gene | ACSF3 |
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| Organism | Homo sapiens |
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| Length | 576 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (60)
Diseases linked to this target (Open Targets).
- combined malonic and methylmalonic acidemia · score 0.81
- hair colour measurement · score 0.49
- methylmalonic acidemia · score 0.48
- skin pigmentation · score 0.43
- genetic disorder · score 0.41
- skin pigmentation measurement · score 0.37
- neutrophil count · score 0.33
- sunburn · score 0.30
- mean corpuscular hemoglobin · score 0.28
- mean corpuscular volume · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4G176-F1 | alphafold | PREDICTED | 86.16 | — |
Amino-acid sequence (576 residues)
MLPHVVLTFR RLGCALASCR LAPARHRGSG LLHTAPVARS DRSAPVFTRA LAFGDRIALV DQHGRHTYRE LYSRSLRLSQ EICRLCGCVG GDLREERVSF LCANDASYVV AQWASWMSGG VAVPLYRKHP AAQLEYVICD SQSSVVLASQ EYLELLSPVV RKLGVPLLPL TPAIYTGAVE EPAEVPVPEQ GWRNKGAMII YTSGTTGRPK GVLSTHQNIR AVVTGLVHKW AWTKDDVILH VLPLHHVHGV VNALLCPLWV GATCVMMPEF SPQQVWEKFL SSETPRINVF MAVPTIYTKL MEYYDRHFTQ PHAQDFLRAV CEEKIRLMVS GSAALPLPVL EKWKNITGHT LLERYGMTEI GMALSGPLTT AVRLPGSVGT PLPGVQVRIV SENPQREACS YTIHAEGDER GTKVTPGFEE KEGELLVRGP SVFREYWNKP EETKSAFTLD GWFKTGDTVV FKDGQYWIRG RTSVDIIKTG GYKVSALEVE WHLLAHPSIT DVAVIGVPDM TWGQRVTAVV TLREGHSLSH RELKEWARNV LAPYAVPSEL VLVEEIPRNQ MGKIDKKALI RHFHPS
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