About Tyrosine-protein phosphatase non-receptor type 20
Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) is a protein
from Homo sapiens identified by UniProt accession
Q4JDL3, 420 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 20 |
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| UniProt accession | Q4JDL3 |
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| Gene | PTPN20 |
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| Organism | Homo sapiens |
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| Length | 420 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- gonorrhea · score 0.07
- body height · score 0.05
- hereditary hyperferritinemia with congenital cataracts · score 0.05
- Hydrocephalus · score 0.05
- Cataract-microcornea syndrome · score 0.05
- megalencephaly, autosomal dominant · score 0.04
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
- isolated ectopia lentis · score 0.04
- Craniosynostosis - Dandy-Walker malformation - hydrocephalus · score 0.04
- craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4JDL3-F1 | alphafold | PREDICTED | 77.96 | — |
Amino-acid sequence (420 residues)
MSSPRDFRAE PVNDYEGNDS EAEDLNFRET LPSSSQENTP RSKVFENKVN SEKVKLSLRN FPHNDYEDVF EEPSESGSDP SMWTARGPFR RDRWSSEDEE AAGPSQALSP LLSDTRKIVS EGELDQLAQI RPLIFNFHEQ TAIKDCLKIL EEKTAAYDIM QEFMALELKN LPGEFNSGNQ PSNREKNRYR DILPYDSTRV PLGKSKDYIN ASYIRIVNCG EEYFYIATQG PLLSTIDDFW QMVLENNSNV IAMITREIEG GIIKCYHYWP ISLKKPLELK HFRVFLENYQ ILQYFIIRMF QVVEKSTGTS HSVKQLQFTK WPDHGTPASA DSFIKYIRYA RKSHLTGPMV VHCSAGIGRT GVFLCVDVVF CAIVKNCSFN IMDIVAQMRE QRSGMVQTKE QYHFCYDIVL EVLRKLLTLD
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