About TBC1 domain family member 10B
TBC1 domain family member 10B (TBC1D10B) is a protein
from Homo sapiens identified by UniProt accession
Q4KMP7, 808 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | TBC1 domain family member 10B |
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| UniProt accession | Q4KMP7 |
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| Gene | TBC1D10B |
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| Organism | Homo sapiens |
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| Length | 808 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.09
- creatinine measurement · score 0.08
- FEV/FVC ratio · score 0.07
- mean corpuscular volume · score 0.07
- mean platelet volume · score 0.06
- neoplasm · score 0.06
- platelet component distribution width · score 0.03
- cancer · score 0.03
- reticulocyte count · score 0.02
- hepatocellular carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4KMP7-F1 | alphafold | PREDICTED | 67.02 | — |
Amino-acid sequence (808 residues)
METGTAPLVA PPRRHGAPAA PSPPPRGSRA GPVVVVAPGP PVTTATSAPV TLVAPGEARP AWVPGSAETS APAPAPAPAP APAVTGSTVV VLTLEASPEA PKPQLPSGPE SPEPAAVAGV ETSRALAAGA DSPKTEEARP SPAPGPGTPT GTPTRTPSRT APGALTAKPP LAPKPGTTVA SGVTARSASG QVTGGHGAAA ATSASAGQAP EDPSGPGTGP SGTCEAPVAV VTVTPAPEPA ENSQDLGSTS SLGPGISGPR GQAPDTLSYL DSVSLMSGTL ESLADDVSSM GSDSEINGLA LRKTDKYGFL GGSQYSGSLE SSIPVDVARQ RELKWLDMFS NWDKWLSRRF QKVKLRCRKG IPSSLRAKAW QYLSNSKELL EQNPGKFEEL ERAPGDPKWL DVIEKDLHRQ FPFHEMFAAR GGHGQQDLYR ILKAYTIYRP DEGYCQAQAP VAAVLLMHMP AEQAFWCLVQ ICDKYLPGYY SAGLEAIQLD GEIFFALLRR ASPLAHRHLR RQRIDPVLYM TEWFMCIFAR TLPWASVLRV WDMFFCEGVK IIFRVALVLL RHTLGSVEKL RSCQGMYETM EQLRNLPQQC MQEDFLVHEV TNLPVTEALI ERENAAQLKK WRETRGELQY RPSRRLHGSR AIHEERRRQQ PPLGPSSSLL SLPGLKSRGS RAAGGAPSPP PPVRRASAGP APGPVVTAEG LHPSLPSPTG NSTPLGSSKE TRKQEKERQK QEKERQKQEK EREKERQKQE KEREKQEKER EKQEKERQKQ EKKAQGRKLS LRRKADGPPG PHDGGDRPSA EARQDAYF
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