Dynein axonemal light chain 1 (DNAL1)

About Dynein axonemal light chain 1

Dynein axonemal light chain 1 (DNAL1) is a protein from Homo sapiens identified by UniProt accession Q4LDG9, 190 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Dynein axonemal light chain 1
UniProt accession	Q4LDG9
Gene	DNAL1
Organism	Homo sapiens
Length	190 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

primary ciliary dyskinesia · score 0.68
bronchiectasis · score 0.37
Bronchiectasis · score 0.37
FEV/FVC ratio · score 0.20
genetic disorder · score 0.16
systolic blood pressure · score 0.15
testosterone measurement · score 0.07
Lipedema · score 0.05
Milroy disease · score 0.05
reticulocyte count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4LDG9-F1	alphafold	PREDICTED	94.77	—

Amino-acid sequence (190 residues)

MAKATTIKEA LARWEEKTGQ RPSEAKEIKL YAQIPPIEKM DASLSMLANC EKLSLSTNCI EKIANLNGLK NLRILSLGRN NIKNLNGLEA VGDTLEELWI SYNFIEKLKG IHIMKKLKIL YMSNNLVKDW AEFVKLAELP CLEDLVFVGN PLEEKHSAEN NWIEEATKRV PKLKKLDGTP VIKGDEEEDN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards