Alanine- and arginine-rich domain-containing…

About Alanine- and arginine-rich domain-containing protein

Alanine- and arginine-rich domain-containing protein (AARD) is a protein from Homo sapiens identified by UniProt accession Q4LEZ3, 155 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Alanine- and arginine-rich domain-containing protein
UniProt accession	Q4LEZ3
Gene	AARD
Organism	Homo sapiens
Length	155 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
type 2 diabetes mellitus · score 0.09
fasting blood glucose measurement · score 0.06
diabetes mellitus · score 0.06
glucose measurement · score 0.06
HbA1c measurement · score 0.06
asthma · score 0.06
triglyceride measurement · score 0.06
insulin measurement · score 0.06
BMI-adjusted fasting blood glucose measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4LEZ3-F1	alphafold	PREDICTED	77.59	—

Amino-acid sequence (155 residues)

MGPGDFRRCR ERISQGLQGL PGRAELWFPP RPACDFFGDG RSTDIQEEAL AASPLLEDLR RRLTRAFQWA VQRAISRRVQ EAAAAAAARE EQSWTGVEAT LARLRAELVE MHFQNHQLAR TLLDLNMKVQ QLKKEYELEI TSDSQSPKDD AANPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Alanine- and arginine-rich domain-containing protein (AARD)