About Zinc-regulated GTPase metalloprotein activator 1F
Zinc-regulated GTPase metalloprotein activator 1F (ZNG1F) is a protein
from Homo sapiens identified by UniProt accession
Q4V339, 395 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Zinc-regulated GTPase metalloprotein activator 1F |
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| UniProt accession | Q4V339 |
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| Gene | ZNG1F |
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| Organism | Homo sapiens |
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| Length | 395 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- congenital hydronephrosis · score 0.07
- ureteral neoplasm · score 0.07
- ureter cancer · score 0.07
- ureterocele · score 0.07
- familial vesicoureteral reflux · score 0.06
- congenital primary megaureter · score 0.06
- multicystic dysplastic kidney · score 0.06
- visual perception measurement · score 0.06
- Genetic renal or urinary tract malformation · score 0.06
- renal hypodysplasia/aplasia 3 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4V339-F1 | alphafold | PREDICTED | 75.52 | — |
Amino-acid sequence (395 residues)
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTL RSINGLGQIL ETQRSRVDLS NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFD VPGNAKEEHL NMFIQNLLWE KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELCDL EETPVSWKDD TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
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