About Putative protein MSS51 homolog, mitochondrial
Putative protein MSS51 homolog, mitochondrial (MSS51) is a protein
from Homo sapiens identified by UniProt accession
Q4VC12, 460 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Putative protein MSS51 homolog, mitochondrial |
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| UniProt accession | Q4VC12 |
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| Gene | MSS51 |
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| Organism | Homo sapiens |
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| Length | 460 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- Familial partial lipodystrophy, Köbberling type · score 0.04
- long chain 3-hydroxyacyl-CoA dehydrogenase deficiency · score 0.04
- PLIN1-related familial partial lipodystrophy · score 0.04
- multiple symmetric lipomatosis · score 0.04
- autosomal dominant mitochondrial myopathy with exercise intolerance · score 0.04
- Isolated CoQ-cytochrome C reductase deficiency · score 0.04
- LIPE-related familial partial lipodystrophy · score 0.04
- familial partial lipodystrophy, Dunnigan type · score 0.04
- carnitine palmitoyl transferase II deficiency, severe infantile form · score 0.04
- hyperinsulinism due to INSR deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4VC12-F1 | alphafold | PREDICTED | 87.31 | — |
Amino-acid sequence (460 residues)
MAPRSRRRRH KKPPSSVAPI IMAPTTIVTP VPLTPSKPGP SIDTLGFFSL DDNVPGLSQL ILQKLNMKSY EEYKLVVDGG TPVSGFGFRC PQEMFQRMED TFRFCAHCRA LPSGLSDSKV LRHCKRCRNV YYCGPECQKS DWPAHRRVCQ ELRLVAVDRL MEWLLVTGDF VLPSGPWPWP PEAVQDWDSW FSMKGLHLDA TLDAVLVSHA VTTLWASVGR PRPDPDVLQG SLKRLLTDVL SRPLTLGLGL RALGIDVRRT GGSTVHVVGA SHVETFLTRP GDYDELGYMF PGHLGLRVVM VGVDVATGFS QSTSTSPLEP GTIQLSAHRG LYHDFWEEQV ETGQTHHPDL VAAFHPGFHS SPDLMEAWLP TLLLLRDYKI PTLITVYSHQ ELVSSLQILV ELDTHITAFG SNPFMSLKPE QVYSSPNKQP VYCSAYYIMF LGSSCQLDNR QLEEKVDGGI
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