HIG1 domain family member 2B (HIGD2B)

About HIG1 domain family member 2B

HIG1 domain family member 2B (HIGD2B) is a protein from Homo sapiens identified by UniProt accession Q4VC39, 106 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	HIG1 domain family member 2B
UniProt accession	Q4VC39
Gene	HIGD2B
Organism	Homo sapiens
Length	106 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

body mass index · score 0.17
body height · score 0.12
vital capacity · score 0.09
triglyceride measurement · score 0.07
gut microbiome measurement · score 0.05
physical activity measurement · score 0.05
visceral adipose tissue measurement · score 0.04
waist-hip ratio · score 0.03
dilated cardiomyopathy 1I · score 0.03
grip strength measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4VC39-F1	alphafold	PREDICTED	61.01	—

Amino-acid sequence (106 residues)

MATLGFVTPE APFESSKPPI FEGLSPTVYS NPEGFKEKFL RKTRENPVVP IGFLCTAAVL TNGLYCFHQG NSQCSRLMMH TQIAAQGFTI AAILLGLAAT AMKSPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards