About FLYWCH-type zinc finger-containing protein 1
FLYWCH-type zinc finger-containing protein 1 (FLYWCH1) is a protein
from Homo sapiens identified by UniProt accession
Q4VC44, 716 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | FLYWCH-type zinc finger-containing protein 1 |
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| UniProt accession | Q4VC44 |
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| Gene | FLYWCH1 |
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| Organism | Homo sapiens |
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| Length | 716 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- acroleukopathy, symmetric · score 0.07
- familial progressive hyperpigmentation · score 0.07
- linear atrophoderma of Moulin · score 0.07
- Dowling-Degos disease 1 · score 0.07
- familial generalized lentiginosis · score 0.07
- Neurofibromatosis type 6 · score 0.07
- acute myeloid leukemia · score 0.06
- dyschromatosis symmetrica hereditaria · score 0.06
- Dyschromatosis universalis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4VC44-F1 | alphafold | PREDICTED | 63.51 | — |
Amino-acid sequence (716 residues)
MPLPEPSEQE GESVKAGQEP SPKPGTDVIP AAPRKPREFS KLVLLTASDQ DEDGVGSKPQ EVHCVLSLEM AGPATLASTL QILPVEEQGG VVQPALEMPE QKCSKLDAAA PQSLEFLRTP FGGRLLVLES FLYKQEKAVG DKVYWKCRQH AELGCRGRAI TRGLRATVMR GHCHAPDEQG LEARRQREKL PSLALPEGLG EPQGPEGPGG RVEEPLEGVG PWQCPEEPEP TPGLVLSKPA LEEEEAPRAL SLLSLPPKKR SILGLGQARP LEFLRTCYGG SFLVHESFLY KREKAVGDKV YWTCRDHALH GCRSRAITQG QRVTVMRGHC HQPDMEGLEA RRQQEKAVET LQAGQDGPGS QVDTLLRGVD SLLYRRGPGP LTLTRPRPRK RAKVEDQELP TQPEAPDEHQ DMDADPGGPE FLKTPLGGSF LVYESFLYRR EKAAGEKVYW TCRDQARMGC RSRAITQGRR VTVMRGHCHP PDLGGLEALR QREKRPNTAQ RGSPGGPEFL KTPLGGSFLV YESFLYRREK AAGEKVYWTC RDQARMGCRS RAITQGRRVM VMRRHCHPPD LGGLEALRQR EHFPNLAQWD SPDPLRPLEF LRTSLGGRFL VHESFLYRKE KAAGEKVYWM CRDQARLGCR SRAITQGHRI MVMRSHCHQP DLAGLEALRQ RERLPTTAQQ EDPEKIQVQL CFKTCSPESQ QIYGDIKDVR LDGESQ
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